Two sample MR report
CFB_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | -0.0276062 | 0.0207167 | 0.1984392 |
| Weighted median | 21 | 0.0052018 | 0.0035644 | 0.1444677 |
| Inverse variance weighted | 21 | 0.0055356 | 0.0026596 | 0.0374009 |
| Simple mode | 21 | 0.0045358 | 0.0067348 | 0.5083502 |
| Weighted mode | 21 | 0.0038724 | 0.0065450 | 0.5607105 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.893374 | 19 | 0.9877120 |
| Inverse variance weighted | 10.495499 | 20 | 0.9582723 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0413357 | 0.0256248 | 0.1232067 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003345 | 0 | TRUE | 0.0822893 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
